Focused processed hACE2?+?XBB1
Focused processed hACE2?+?XBB1.5 RBD (PDB ID: 8VKP, EMDB ID: EMD-43325). complexes derived from donor serum are deposited together under the following EMDB access: Unfavorable Stain EM Reconstructions of SARS-CoV-2 spike proteins mixed with polyclonal antibodies from donor 4 (EMDB ID: EMD-43326)?Source data are provided with this paper. Abstract The XBB.1.5 KGF variant of SARS-CoV-2 has rapidly achieved global dominance and exhibits a high growth advantage over previous variants. Preliminary reports CO-1686 (Rociletinib, AVL-301) suggest that the success of XBB.1.5 stems from mutations within its spike glycoprotein, causing immune evasion and enhanced receptor binding. We present CO-1686 (Rociletinib, AVL-301) receptor binding studies that demonstrate retention of binding contacts with the human ACE2 receptor and a striking decrease in binding to mouse ACE2 due to the revertant R493Q mutation. Despite considerable evasion…