These events may account for the escape of fibroblasts from a control attempted by T cells and for the resistance to apoptosis (12C15)
These events may account for the escape of fibroblasts from a control attempted by T cells and for the resistance to apoptosis (12C15). and sandwich ELISA, respectively. Co-cultured and control fibroblasts were also stained with Annexin V and analyzed by circulation cytometry. Results: T cellCfibroblast co-cultures overexpressed and and (6). These data suggest that an antigen-driven T-cell response could be initially devoted to control the aberrant fibroblast activation found in SSc. In line with our observations, additional authors reported that chemically pre-activated peripheral T cells from SSc individuals can also induce autologous fibroblast apoptosis after a short-term exposure (7). In those experiments, both T cellCfibroblast connection and activation of T cells was paralleled by a cytokine burst in which profibrotic cues were more prominent (5, 6, 8, 9). These events…