[PubMed] [Google Scholar] 2
[PubMed] [Google Scholar] 2. B-cells through the actions of follicular T-helper and follicular dendritic cells. BCL6 also represses genes involved in terminal differentiation such as IRF4 and PRDM1 [1,4], and so must be downregulated for exit from the GC reaction to occur. Hence BCL6 not only enables but also maintains the GC B-cell phenotype. The checkpoint suppression properties of BCL6 are inherently pro-oncogenic and accordingly BCL6 is almost universally expressed in DLBCLs. DLBCLs can be subclassified according to gene expression profiles into various disease subtypes. Among these the ABC (activated B-cell)-DLBCLs are OSU-03012 generally considered to be derived from late GC B-cells in which BCL6 downregulation would normally occur [6]. Accordingly ABC-DLBCLs feature more frequent translocation of the BCL6 locus to heterologous promoters allowing for its constitutive expression. Although ABC-DLBCLs…