Macaque icons used in Fig
Macaque icons used in Fig.?2a were created on BioRender.com. safeguarded macaques post challenge show total CCR5 receptor occupancy and an absence of viral nucleic acids. After Leronlimab washout, safeguarded macaques remain aviremic, and adoptive transfer of hematologic cells into na?ve macaques does not transmit viral infection. These data determine CCR5 blockade with Leronlimab like a promising approach to HIV prophylaxis and support initiation of medical trials. Subject terms: Antibody therapy, HIV infections CCR5 is definitely a co-receptor for many transmitted HIV strains. Here, the authors display that biweekly injection of the CCR5-specific antibody Leronlimab protects rhesus macaques against illness following repeated intrarectal difficulties of a CCR5-tropic SHIV. Intro Pre-exposure prophylaxis (PrEP) is effective for HIV prevention, where drug concentrations in the blood are strongly correlated with safety1,2. However, the effectiveness…