( em C /em ) Expression of D3 in human tissues and skin cells: (1,9) DNA ladder; (2) pituitary; (3,4) normal skin; (5) BCC; (6) myometrium; (7) follicular keratinocytes; (8) epidermal keratinocytes; (10) epidermal melanocytes; (11C13) SBCE2,WM35, and WM98 melanomas, respectively
( em C /em ) Expression of D3 in human tissues and skin cells: (1,9) DNA ladder; (2) pituitary; (3,4) normal skin; (5) BCC; (6) myometrium; (7) follicular keratinocytes; (8) epidermal keratinocytes; (10) epidermal melanocytes; (11C13) SBCE2,WM35, and WM98 melanomas, respectively. samples. Expression of functional thyroid-stimulating hormone receptor in the skin may have significant physiologic and pathologic consequences, particularly in autoimmune conditions associated with production of stimulating antibodies against the thyroid-stimulating hormone receptor. We conclude that the expanding list of neuroendocrine elements expressed in the IL18RAP skin supports a strong role for this system in cutaneous biology. production of thyroid hormones in human skin has not yet been demonstrated, although epidermal keratinocytes may be capable of deiodinating thyroxine (T4) and T3 (reviewed in Slominski and Wortsman, 2000). Fibroblasts of human…