Means SEM are shown
Means SEM are shown. tumor growth in mice. These findings show that TIPE2 takes on a key part in the practical polarization of MDSCs and represents a new therapeutic target for malignancy immunotherapy. Graphical Abstract Open in a separate window Intro Myeloid-derived suppressor cells (MDSCs) are a heterogeneous subpopulation of leukocytes important for tumor and inflammatory diseases (Bronte et al., 2016; He et al., 2018; Kumar et al., 2016b; Manjili, 2012; Solito et al., 2012; Trikha and Carson, 2014; Zhou et al., 2018). Although MDSCs are present in low figures in healthy individuals, they increase markedly in individuals with malignancy or chronic swelling (comprising 10% of leukocytes in the blood or spleen; Bronte et al., 2016; Gabrilovich, 2017; Kumar et al., 2016b; Manjili, 2012; Solito et al., 2012; Trikha and…