Mouse handling and the experimental procedures were approved by the Seoul National University Institutional Animal Care and Use Committees (permit numbers: SNU-150612-4) and were performed in accordance with the approved guidelines
Mouse handling and the experimental procedures were approved by the Seoul National University Institutional Animal Care and Use Committees (permit numbers: SNU-150612-4) and were performed in accordance with the approved guidelines. via p38 MAPK plays a central role in the rapid synthesis of pro-IL-1 in response to MSU crystals, which is an essential step for IL-1 production in human monocytes. Inflammation is an essential part of the immune response, which is aimed at removing harmful stimuli and maintaining host tissue integrity1,2. Innate immune cells play a pivotal role for launching inflammatory responses after Arteether sensing infectious pathogens or tissue injury through a variety of pattern recognition receptors (PPRs)3,4,5. It is now evident that sterile inflammation, which is caused by damage-associated molecular pattern (DAMP) molecules endogenously derived from host tissue injury…