{"id":1031,"date":"2026-06-18T05:20:32","date_gmt":"2026-06-18T05:20:32","guid":{"rendered":"http:\/\/changingfaceofamerica.com\/?p=1031"},"modified":"2026-06-18T05:20:32","modified_gmt":"2026-06-18T05:20:32","slug":"however-after-the-adjusting-for-risk-factors-intended-for-cerebrovascular-disease-cimt-and-plaque-no-longer-had-a-significant-relationship-with-ischemic-stroke","status":"publish","type":"post","link":"https:\/\/changingfaceofamerica.com\/?p=1031","title":{"rendered":"\ufeffHowever , after the adjusting for risk factors intended for cerebrovascular disease, CIMT, and plaque no longer had a significant relationship with ischemic stroke"},"content":{"rendered":"

\ufeffHowever , after the adjusting for risk factors intended for cerebrovascular disease, CIMT, and plaque no longer had a significant relationship with ischemic stroke. 14This descriptive study found that average CIMT in patients with diabetes was higher (1. 372 3. 88 mm) than in patients with no history of diabetes (1. 151 2 . 75 mm). The role of VEGF and low-intensity inflammatory process in post-acute ischemic stroke patients remains controversial. CIMT and plasma VEGF levels in patients with post-acute thrombotic stroke (p=0. 741). A significant correlation was recognized between CIMT and total cholesterol (p=0. 029) and low-density lipoprotein (p=0. 018). == Conclusion == There were no significant correlations between CIMT and plasma VEGF levels in patients with post-acute thrombotic stroke. However , plasma VEGF increased in patients with thrombotic stroke. CIMT measurement is a promising noninvasive modality to assess the vascular condition of patients with stroke and diabetes, while plasma VEGF cannot specifically assess vascular condition as it can be brought on by ischemic conditions in tissues from the whole body. Keywords: atherosclerosis, CIMT, VEGF, thrombotic stroke == Introduction == Stroke is the leading cause of death and disability worldwide. In Indonesia, the typical age of stroke patients is 58. 8 years old and stroke is the leading cause of a high mortality price in people above 50 years aged. 13The number of stroke patients is inclined to increase every year, not only among elderly people, but also young and productive people. 4The most common type of stroke is thrombotic stroke with atherosclerosis as the most common cause. 5, 6In atherosclerosis, thickening of the intima causes a decrease in the supply of oxygen to the significantly arterial wall, causing ischemia in blood vessels which provokes the release of factors stimulating angiogenesis of vasa vasorum, such as EPO, VEGF, and Ets-1. 7Other studies have shown the existence of inflammatory responses in the atherosclerotic process, such as the ZXH-3-26 role of PF4 which inhibits the degradation of low-density lipoprotein (LDL), facilitating the oxidation of LDL, recruiting monocytes, and facilitating their differentiation into macrophages. In ZXH-3-26<\/a> addition , platelet factors also act as an anti-angiogenic chemokine by inhibiting VEGF. 8Differences in the theory of relationship between atherosclerosis and VEGF emphasize the examination of the relationship between atherosclerosis and plasma VEGF levels assessed by carotid artery ultrasound. Angiogenesis denotes a vital process in the growth and development of tissues which also takes place in pathological conditions, such as stroke, malignancy, inflammation, and diabetes mellitus. 7, 8Currently, treatment intended for stroke which amplifies angiogenic and neurogenic processes continues to be developed. 9In Indonesia, the blood test intended for VEGF is not yet widely ZXH-3-26 available. This study aims at describing the effects of atherosclerosis examined through carotid intima-media thickness (CIMT) on the angiogenic process examined through the levels of VEGF, which seems to be able to assist clinicians in assessing vascular wellness, so as to provide management and selection of appropriate therapy. == Methods == == Research topics == The research design was observational analytic. The data were collected cross-sectionally from in patients and out patients with post-acute thrombotic stroke in days 7 to 90 in Dr . Saiful Anwar General Hospital Malang, Indonesia. The research subjects were 25 patients who were chosen consecutively. == Inclusion criteria == Patients with clinically diagnosed post-acute thrombotic stroke identified through computed tomography scan or magnetic resonance imaging. Patients must be willing to participate in the research (by filling in informed consent form). Intended for patients with loss of consciousness\/Glasgow Coma Level of less than 15, the consent was obtained from certified family. == Exclusion criteria == Patients who had received intra-arterial thrombolytic therapy. Patients who were distressed which causes difficulties in carotid ultrasound examination. Patients with myocardium infarction and malignancy. == Place and time of research == This study was conducted at Radiology and Neurology Units intended for in patients and out patients at Dr . Saiful Anwar General Hospital Malang and at Physiology Laboratory of Faculty of Medicine, Universitas Brawijaya. == Materials and tools == Materials and tools utilized in this study were USG GE Logiq S6 with linear probe (513 MHz) and enzyme-linked immunosorbent assay (ELISA) with VEGF-A Elab science kit. == Working technique and informed consent == This research was approved by the Medical Study Ethics Committee of Dr . Saiful Anwar General Hospital Malang with certificate no . 400\/12\/K. 3\/302\/2016. Patients provided written knowledgeable consent prior IkB alpha antibody<\/a> to the examination and participation in this study. == Procedures == Carotid ultrasonography was performed under the supervision of two radiology professionals with.<\/p>\n","protected":false},"excerpt":{"rendered":"

\ufeffHowever , after the adjusting for risk factors intended for cerebrovascular disease, CIMT, and plaque no longer had a significant relationship with ischemic stroke. 14This descriptive study found that average CIMT in patients with diabetes was higher (1. 372 3. 88 mm) than in patients with no history of diabetes (1. 151 2 . 75 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-1031","post","type-post","status-publish","format-standard","hentry","category-tachykinin-non-selective"],"_links":{"self":[{"href":"https:\/\/changingfaceofamerica.com\/index.php?rest_route=\/wp\/v2\/posts\/1031","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/changingfaceofamerica.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/changingfaceofamerica.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/changingfaceofamerica.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/changingfaceofamerica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1031"}],"version-history":[{"count":1,"href":"https:\/\/changingfaceofamerica.com\/index.php?rest_route=\/wp\/v2\/posts\/1031\/revisions"}],"predecessor-version":[{"id":1032,"href":"https:\/\/changingfaceofamerica.com\/index.php?rest_route=\/wp\/v2\/posts\/1031\/revisions\/1032"}],"wp:attachment":[{"href":"https:\/\/changingfaceofamerica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1031"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/changingfaceofamerica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1031"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/changingfaceofamerica.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}