More recent study using chromatin immunoprecipitation (ChIP) assay revealed that nerve injury promotes histone H3 and H4 acetylation at BDNF promoter I at day 1 post-injury in the DRG, and the levels of histone acetylation remain elevated for at least 7 days suggesting that an initial increase in BDNF exon I expression controlled by epigenetic mechanisms might play a crucial role in the development of neuropathic pain [57]
More recent study using chromatin immunoprecipitation (ChIP) assay revealed that nerve injury promotes histone H3 and H4 acetylation at BDNF promoter I at day 1 post-injury in the DRG, and the levels of histone acetylation remain elevated for at least 7 days suggesting that an initial increase in BDNF exon I expression controlled by epigenetic mechanisms might play a crucial role in the development of neuropathic pain [57]. Oxytocin Oxytocin (OXT), a nine amino acid neuropeptide, is regarded as the love hormone found to be involved in a wide variety of physiological and pathological functions. activation of NMUR1 that couples sequentially to the downstream activities of G of the G[o] protein, PKA, and ERK, which could contribute to its physiological functions including neuronal hypoexcitability in DRG neurons, and NMU inhibits…