Indeed, loss of vasodilatory and anti-platelet effects of NO may result in CVD initiation and progression
Indeed, loss of vasodilatory and anti-platelet effects of NO may result in CVD initiation and progression. reactive oxygen species. This review focuses on the clinically validated targets of oxidative stress, NO synthase (NOS) and the NO receptor, soluble guanylate cyclase as well as the source of ROS, e.g. NADPH oxidases. We place recent knowledge in the function and regulation of these enzyme families into clinical perspective. For a comprehensive overview of the biology and pharmacology of oxidative stress and possible other sources and targets, we refer to other literature overviews. strong class="kwd-title" Keywords: Nitric oxide, Reactive oxygen species, Oxidative stress, sGC activators, sGC stimulators, NADPH oxidases (NOX), Soluble guanylate cyclase In cardiovascular diseases (CVD) such as hypertension, atherosclerosis and chronic heart failure, endothelial dysfunction correlates with and can even predict…