[PMC free content] [PubMed] [CrossRef] [Google Scholar] 15
[PMC free content] [PubMed] [CrossRef] [Google Scholar] 15. results offer concrete proof that devastation of the precise SeV receptor, 2,3-connected sialic acids, is pertinent to homologous disturbance by SeV. IMPORTANCE Viral disturbance is certainly a noticed sensation, but the specific mechanism isn't apparent. Using SeV disturbance, we offer concrete proof that reduced amount of the two 2,3-connected sialic acid solution receptor with the HN of SeV is certainly related to viral interference closely. Since SeV infections resulted in Helicid loss of just 2,3-connected sialic acids, IAV, which utilized 2 also,6-connected sialic acids to start infections, superinfected the SeV-infected cells. On the other hand, SeV cannot superinfect the IAV-infected cells because both 2,3- and 2,6-connected sialic acids had been removed. These results indicate that receptor destruction plays a part in viral…