Moreover, O-glycosylation is not restricted to secreted proteins and to date, no consensus sequences have been identified for this PTM
Moreover, O-glycosylation is not restricted to secreted proteins and to date, no consensus sequences have been identified for this PTM.88 ECM proteins may be extensively modified by addition of N- and O-linked large and repetitive glycosaminoglycans (GAGs) and shorter and diverse N- and O-linked oligosaccharides. be interrogated by proteomic techniques. summarizes important findings in clinical studies as well as in animal models of cardiac disease.5C42 Additional studies reported ECM proteins as potential biomarkers for cardiac pathologies43; these have been intentionally omitted from the table, the focus of Inolitazone dihydrochloride which are ECM and ECM-associated proteins (i.e. extracellular proteases and non-structural proteins that bind to or regulate ECM) from a functional perspective. Most proteins included in the table were individually studied using antibodies and loss-of-function models in order to assign their…