While residue Arg884 in the opinions inhibitor-binding pocket of C3 PEPC provides an additional hydrogen relationship to the inhibitor and promotes stronger binding, the corresponding residue Gly884 in C4 PEPC reduces the steric restriction of the binding site and provides fewer contacts with the inhibitor
While residue Arg884 in the opinions inhibitor-binding pocket of C3 PEPC provides an additional hydrogen relationship to the inhibitor and promotes stronger binding, the corresponding residue Gly884 in C4 PEPC reduces the steric restriction of the binding site and provides fewer contacts with the inhibitor. limited inhibitor binding Ketoconazole in the C3-type enzyme. In the C4 phosphoenolpyruvate carboxylase isoform, this arginine is definitely replaced by glycine. The substitution reduces inhibitor affinity and enables the enzyme to participate in the C4 photosynthesis pathway. Based on the type of CO2 assimilation, vegetation can be divided into three photosynthetic types: the C3-type, the C4-type and the Crassulacean Acid Rate of metabolism1. In the classical C3-photosynthetic pathway, the primary CO2 fixation is definitely catalysed from the enzyme ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) resulting in the formation…