This shows that monovalent inhibitors should be present at saturating levels to disrupt the interactions of cell surface sialoglycans with immobilized MAG

Cell Signaling
This shows that monovalent inhibitors should be present at saturating levels to disrupt the interactions of cell surface sialoglycans with immobilized MAG. proteins from the NgR family members, NgR1 (5, 6) and NgR2 (7), which might also end up being axonal ligands for Nogo and OMgp (8). You can find conflicting data regarding the sialidase awareness of MAG-NgR binding (5C7). Even though the comparative jobs of NgRs and gangliosides as MAG ligands possess however to become solved, in a few systems MAG inhibition is certainly reversed by sialidase totally, suggesting that, at least in those functional systems, MAG uses sialylated glycans as its main axonal ligands. In those operational systems, or in conjunction with blockers of NgR (9), it really MSX-122 is anticipated that potent glycan inhibitors of MAG may…
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