Detergent cell extracts were immunoprecipitated with anti-JAK2

Alpha2 Adrenergic Receptors
Detergent cell extracts were immunoprecipitated with anti-JAK2. exhibited markedly different sensitivity to inducible GHR proteolysis, which correlated directly to their relative levels of mature TACE vs unprocessed TACE precursor and indirectly to their levels of cellular TIMP3. Our results implicate TIMP3 as a modulator of cell surface GHR abundance and the ability of GH to promote cellular signaling; these modulatory effects may be conferred by endogenous TIMP3 expression as well as exogenous TIMP3 exposure. Furthermore, our analysis suggests that TIMP3, in addition to regulating the activity of TACE, may also modulate the maturation of TACE, thereby affecting the abundance of the active form of the enzyme. GH is a 22-kDa polypeptide vertebrate hormone derived largely from the anterior pituitary gland. GH signals powerful somatogenic and metabolic effects and may have…
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