More recently, fisetin has also been reported to target Aurora B kinase, a Ser/Thr kinase involved in ensuring proper microtubule attachment at the spindle assembly checkpoint, and an enzyme that is overexpressed in several types of cancer
More recently, fisetin has also been reported to target Aurora B kinase, a Ser/Thr kinase involved in ensuring proper microtubule attachment at the spindle assembly checkpoint, and an enzyme that is overexpressed in several types of cancer. were also seen with the model Aurora kinase inhibitors. These results indicate that fisetin induces multiple types of chromosome abnormalities in human cells, and indicate a need for a thorough investigation of fisetin-augmented dietary supplements. as well as inhibition of critical enzymes such as cyclin-dependent kinases and topoisomerase II [4C10]. Earlier reports from our laboratory and others have indicated that fisetin has both aneugenic and, to a lessor degree, clastogenic properties in cultured cells [9, 11, 12]. Recently, fisetin has also been reported to target Aurora B kinase, a Ser/Thr kinase involved in…