As a result of their high lipophilicity, masked nucleotides are able to penetrate cell membranes in their intact form and are therefore not prone to degradation by nonspecific plasma phosphatases
As a result of their high lipophilicity, masked nucleotides are able to penetrate cell membranes in their intact form and are therefore not prone to degradation by nonspecific plasma phosphatases. poly(ADP-ribose) polymerase (PARP-1), which is definitely involved in the identification of damages deriving from reactive oxygen species [14]. Recently, some small molecules based on nicotinamide analogs have been reported to function as inhibitors of PARP-1 [15,16]. An interesting result was acquired using PARP-1 inhibitors against BRCA1 and BRCA2 deficient tumor cells, in which killing was specifically directed again these cells with minimal effects on wild-type Moclobemide cells [17,18]. BRCA1 and BRCA2 proteins Moclobemide are involved in restoration of DNA damage through the HR pathways and cells defective in these two proteins are unable to solve replication forks stalling caused by…